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5-Aminolevulinic acid hydrochloride

CAS号

5451-09-2

分子式

C5H10ClNO3

主要靶点

Endogenous Metabolite|Autophagy|Mitophagy|Apoptosis

仅限科研使用

Cat No : CM00011

Print datasheet

Synonyms

Autophagy|Apoptosis|ALA Hydrochloride|ALA hydrochloride|5-氨基乙酰丙酸盐酸盐|5 Aminolevulinic acid hydrochloride|5-ALA|5-Aminolevulinic acid|5-Aminolevulinic acid HCl|5Aminolevulinic acid hydrochloride|5-Aminolevulinic acid Hydrochloride|Endogenous Metabolite|inhibit|Hydrangin|EndogenousMetabolite|Inhibitor|Mitophagy|Mitochondrial Autophagy|氨基酮戊酸|δ-Aminolevulinic acid

验证数据展示

  • CAS No.: 5451-09-2

    5-Aminolevulinic acid hydrochloride
    CAS#: 5451-09-2

产品信息

CAS号 5451-09-2
分子式 C5H10ClNO3
主要靶点 Endogenous Metabolite|Autophagy|Mitophagy|Apoptosis
主要通路 代谢|凋亡|自噬|自噬
分子量 167.59
纯度 99.77%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Autophagy|Apoptosis|ALA Hydrochloride|ALA hydrochloride|5-氨基乙酰丙酸盐酸盐|5 Aminolevulinic acid hydrochloride|5-ALA|5-Aminolevulinic acid|5-Aminolevulinic acid HCl|5Aminolevulinic acid hydrochloride|5-Aminolevulinic acid Hydrochloride|Endogenous Metabolite|inhibit|Hydrangin|EndogenousMetabolite|Inhibitor|Mitophagy|Mitochondrial Autophagy|氨基酮戊酸|δ-Aminolevulinic acid

体外活性

5-Aminolevulinic acid 是一种非荧光前药，能导致恶性胶质瘤细胞内荧光卟啉的积累，这一发现正被研究用于术中识别和切除这些肿瘤。中位随访时间为35.4个月（95% CI 1.0-56.7）。与分配白光的131名患者中有47名（36%）完全切除增强对比的肿瘤不同，分配5-Aminolevulinic acid 的139名患者中有90名（65%）实现了完全切除（两组间差异29% [95% CI 17-40], p<0.0001）。与分配白光的患者相比，分配5-Aminolevulinic acid的患者6个月无进展生存率更高（41.0% [32.8-49.2] 对比 21.1% [14.0-28.2]；两组间的差异为19.9% [9.1-30.7], p=0.0003, Z检验）[1]。仅使用5-ALA在实现完全切除肿瘤时证明是不够的，且存在术后神经功能恶化的风险。此外，对于功能级别III的胶质瘤，使用iMRI结合功能性导航相比5-ALA切除技术明显优越[2]。

溶解度

Ethanol:6 mg/mL (35.8 mM);DMSO:45 mg/mL (268.51 mM);H2O:31 mg/mL (185 mM)

参考文献

1.Karmakar S, et al. Neurosci Lett,2007, 415(3), 242-247.
2.Onuki J, et al. Arch Biochem Biophys,2004, 432(2), 178-187.
3.Emanuelli T, et al. Neurochem Int,2001, 38(3), 213-218.
4.Jan CR, et al. Biochim Biophys Acta,1999, 1448(3), 533-542.
5.Cheng J, et al. Int J Nanomedicine,2013, 8, 669-676.

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