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4'-Methoxyresveratrol

CAS号

33626-08-3

分子式

C15H14O3

主要靶点

advanced glycation end products

仅限科研使用

Cat No : CM11587

Print datasheet

Synonyms

RAGE|inhibit|Inhibitor|白藜芦醇-4'-甲醚|advanced glycation end products|advancedglycationendproducts|4' Methoxyresveratrol|4'Methoxyresveratrol|4'-Methoxyresveratrol|4'-O-Methylresveratrol

验证数据展示

  • CAS No.: 33626-08-3

    4'-Methoxyresveratrol
    CAS#: 33626-08-3

产品信息

CAS号 33626-08-3
分子式 C15H14O3
主要靶点 advanced glycation end products
主要通路 其他
分子量 242.27
纯度 99.03%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 RAGE|inhibit|Inhibitor|白藜芦醇-4'-甲醚|advanced glycation end products|advancedglycationendproducts|4' Methoxyresveratrol|4'Methoxyresveratrol|4'-Methoxyresveratrol|4'-O-Methylresveratrol

体外活性

4'-Methoxyresveratrol 显著减弱了NOD样受体含有吡啶结构域3（NLRP3）炎症小体的激活，包括NLRP3和裂解的caspase-1，并减少了成熟IL-1β的分泌。4'-Methoxyresveratrol 的抗炎作用主要通过抑制RAGE介导的MAPK/NF-κB信号通路和NLRP3炎症小体激活来实现。4'-Methoxyresveratrol 可能成为治疗炎症相关疾病的新型化合物。

溶解度

DMSO:60 mg/mL (247.66 mM)

参考文献

1.Wenzhe Y , Mengru T , Yueliang Z , et al. 4′-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway[J]. Molecules, 2018, 23(6):1447-.

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