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4'-Methoxyresveratrol

4'-Methoxyresveratrol (4'-O-Methylresveratrol) 是一种多酚类化合物，来源于双翅目植物中，具有抗雄激素、抗真菌和抗炎症作用。它能抑制 RAGE- 介导的 MAPK/NF-κB 信号通路，并激活 NLRP3 炎性体，从而缓解 AGE- 诱导的炎症。

CAS号

33626-08-3

分子式

C15H14O3

主要靶点

advanced glycation end products

仅限科研使用

Cat No : CM11587

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Synonyms

4'-O-Methylresveratrol|白藜芦醇-4'-甲醚

验证数据展示

  • CAS No.: 33626-08-3

    4'-Methoxyresveratrol
    CAS#: 33626-08-3

产品信息

4'-Methoxyresveratrol is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.

CAS号 33626-08-3
分子式 C15H14O3
主要靶点 advanced glycation end products
主要通路 其他
分子量 242.27
纯度 99.03%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 4'-O-Methylresveratrol|白藜芦醇-4'-甲醚

体外活性

4'-Methoxyresveratrol significantly abated the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome including NLRP3 and cleaved caspase-1 and reduced the secretion of mature IL-1β. The anti-inflammatory effect of 4'-Methoxyresveratrol is mainly through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. 4'-Methoxyresveratrol could be a novel therapeutic agent for inflammation-related diseases.

溶解度

DMSO:48 mg/mL (198.13 mM)

参考文献

1.Wenzhe Y , Mengru T , Yueliang Z , et al. 4′-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway[J]. Molecules, 2018, 23(6):1447-.

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