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4-Hydroxynonenal

CAS号

75899-68-2

分子式

C9H16O2

主要靶点

Endogenous Metabolite|Dehydrogenase

仅限科研使用

Cat No : CM11564

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Synonyms

stress|inhibit|Inhibitor|mitochondria|nitrosative|oxidative|Endogenous Metabolite|Human Endogenous Metabolite|genotoxic|EndogenousMetabolite|4Hydroxynonenal|4-Hydroxynonenal|4-HNE|4-羟基壬烯醛|4 Hydroxynonenal|Aldehyde Dehydrogenase (ALDH)|ALDH|ALDH2|biomarker|Cancer

验证数据展示

  • CAS No.: 75899-68-2

    4-Hydroxynonenal
    CAS#: 75899-68-2

产品信息

CAS号 75899-68-2
分子式 C9H16O2
主要靶点 Endogenous Metabolite|Dehydrogenase
主要通路 代谢|代谢
分子量 156.22
纯度 95.12%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 stress|inhibit|Inhibitor|mitochondria|nitrosative|oxidative|Endogenous Metabolite|Human Endogenous Metabolite|genotoxic|EndogenousMetabolite|4Hydroxynonenal|4-Hydroxynonenal|4-HNE|4-羟基壬烯醛|4 Hydroxynonenal|Aldehyde Dehydrogenase (ALDH)|ALDH|ALDH2|biomarker|Cancer

体内活性

在流体撞击损伤（FPI）24小时后，对小鼠大脑组织进行了NADPH氧化酶1（NOX1）、诱导性一氧化氮合酶（iNOS）、4-Hydroxynonenal （4-HNE）表达水平进行了分析。相较于未受伤的Nrf2+/+和Nrf2-/-小鼠，野生型（Nrf2+/+）和Nrf2缺陷型小鼠（Nrf2-/-）在15 psi损伤（中度损伤）后4-Hydroxynonenal 的表达水平均出现上升。与iNOS结果相似，在Nrf2-/-敲除（KO）小鼠中，与相应受伤和未受伤的Nrf2+/+野生型（WT）动物相比，4-Hydroxynonenal 的表达水平显著上升[2]。

体外活性

4-Hydroxynonenal 同时是ALDH2的底物和抑制剂；在低浓度下，对ALDH2的抑制是可逆的，而当4-HNE浓度达到10 μM时变为不可逆。4-Hydroxynonenal能诱导抗氧化防御机制，限制自身产生并增强细胞对抗氧化应激的保护。作为脂质过氧化的产物，4-Hydroxynonenal在病毒、细菌和哺乳动物细胞中具有突变原性和基因毒性。它与四种DNA碱基反应，但效率不同：G > C > A > T。4-Hydroxynonenal-dG是4-Hydroxynonenal基因毒性效应的最佳生物标志物，这些加合物主要存在于核DNA中[1]。

溶解度

DMSO:249 mg/mL (1593.91 mM)

参考文献

1.Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.
2.Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852(5):826-38.
3.Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl). 2019 Nov 22.

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