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4'-Hydroxychalcone

4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) 是从甘草根中分离的一种查尔酮，具有保护肝脏的作用。它能诱导大鼠离体肝线粒体囊泡快速释放钾，并引起其线粒体呼吸控制和氧化磷酸化衰退。它能通过抑制蛋白酶体 (proteasome)，抑制TNFα 诱导的 NF-κB 活性。

CAS号

2657-25-2

分子式

C15H12O2

主要靶点

Proteasome

仅限科研使用

Cat No : CM01594

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Synonyms

2-Benzal-4-Hydroxyacetophenone|4′-羟基查耳酮|4-羟基查耳酮

验证数据展示

  • CAS No.: 2657-25-2

    4'-Hydroxychalcone
    CAS#: 2657-25-2

产品信息

4'-Hydroxychalcone is a chalcone metabolite with hepatoprotective activity

CAS号 2657-25-2
分子式 C15H12O2
主要靶点 Proteasome
主要通路 蛋白酶体|泛素化
分子量 224.25
纯度 99.71%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 2-Benzal-4-Hydroxyacetophenone|4′-羟基查耳酮|4-羟基查耳酮

溶解度

DMSO:25 mg/mL (1114.83 mM)

参考文献

1.Orlikova B , Tasdemir D , Golais F , et al. The aromatic ketone 4′-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition[J]. biochemical pharmacology, 2011, 82(6):620-631.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2