• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

3-Oxo-5β-cholanoic acid

CAS号

1553-56-6

分子式

C24H38O3

主要靶点

ROR

仅限科研使用

Cat No : CM10594

Print datasheet

Synonyms

differentiation|DHLCA|Dehydrolithocholic acid|inhibit|immune|factor|acid|3 Oxo 5β cholanoic acid|3-氧代-5β-胆烷酸|3-oxoLCA|3-Oxo-5b-cholanoic acid|3-Oxo-5beta-cholanoic acid|3Oxo5βcholanoic acid|3-Oxo-5β-cholanoic acid|cell|bile|Inhibitor|responses|RAR-related orphan receptor|transcription|TH17|RORγt|ROR

验证数据展示

  • CAS No.: 1553-56-6

    3-Oxo-5β-cholanoic acid
    CAS#: 1553-56-6

产品信息

CAS号 1553-56-6
分子式 C24H38O3
主要靶点 ROR
主要通路 代谢
分子量 374.56
纯度 99.77%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 differentiation|DHLCA|Dehydrolithocholic acid|inhibit|immune|factor|acid|3 Oxo 5β cholanoic acid|3-氧代-5β-胆烷酸|3-oxoLCA|3-Oxo-5b-cholanoic acid|3-Oxo-5beta-cholanoic acid|3Oxo5βcholanoic acid|3-Oxo-5β-cholanoic acid|cell|bile|Inhibitor|responses|RAR-related orphan receptor|transcription|TH17|RORγt|ROR

体内活性

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (以0.3% (w/w)的浓度，经口服途径，连续使用1周)能显著降低回肠TH17细胞的比例[1]。

体外活性

处理3-Oxo-5β-cholanoic acid显著降低了RORγt报告基因的活性。3-Oxo-5β-cholanoic acid很可能通过与RORγt的物理相互作用来抑制TH17细胞的分化，并且抑制其转录活性。

溶解度

DMSO:65 mg/ml (173.54 mM)

参考文献

1.Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2