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3-Epioleanolic acid

3-Epioleanolic acid 是一种分离自马鞭草的有效成分，具有抗炎作用。

CAS号

25499-90-5

分子式

C30H48O3

主要靶点

AChR

仅限科研使用

Cat No : CM13042

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Synonyms

验证数据展示

  • CAS No.: 25499-90-5

    3-Epioleanolic acid
    CAS#: 25499-90-5

产品信息

3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.

CAS号 25499-90-5
分子式 C30H48O3
主要靶点 AChR
主要通路 神经科学
分子量 456.7
纯度 98.36%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

In this investigation, the uterotonic properties of extracts from this tree were evaluated using both pregnant and non-pregnant guinea pig uterine smooth muscle in vitro. The extracts were prepared using water modified supercritical carbon dioxide at 400 atm and 80 degrees C. As samples of these extracts displayed positive results when screened for uterotonic activity, gravity column chromatography followed by NMR spectroscopy was performed in an attempt to isolate and elucidate the structures of the compounds that were present in the extract. The extract yielded five known compounds of which only two, viz. oleanonic acid and 3-Epioleanolic acid, displayed uterotonic activity. Receptor binding assays were subsequently performed with 3-Epioleanolic acid to ascertain its mode of action. Bradykinin (30 ng/100 microl) and acetylcholine (1 microg/100 microl) were used as the B2 and cholinergic receptor agonists respectively with icatibant (HOE 140) (30 ng/100 microl) and atropine (60 micro/100 microl) as their corresponding antagonists. 3-Epioleanolic acid was observed to mediate its effect through the cholinergic receptor.

溶解度

DMSO:55 mg/mL (120.43 mM)

参考文献

1.The uterotonic activity of compounds isolated from the supercritical fluid extract of Ekebergia capensis.J Pharm Biomed Anal. 2000 Dec;24(1):133-45.

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