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2-TEDC

2-TEDC 是一种有效的脂氧合酶（LOX）抑制剂，对 5-LOX、12-LOX 和 15-LOX 具有抑制作用，IC50 值分别为 0.09 μM、0.013 μM 和 0.5 μM。2-TEDC 可用于研究动脉粥样硬化。

CAS号

132465-10-2

分子式

C16H13NO4S

主要靶点

Lipoxygenase

仅限科研使用

Cat No : CM04971

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Synonyms

验证数据展示

  • CAS No.: 132465-10-2

    2-TEDC
    CAS#: 132465-10-2

产品信息

2-TEDC is a potent lipoxygenase (LOX) inhibitor with inhibitory effects on 5-LOX, 12-LOX, and 15-LOX with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.2-TEDC can be used in the study of atherosclerosis.

CAS号 132465-10-2
分子式 C16H13NO4S
主要靶点 Lipoxygenase
主要通路 代谢
分子量 315.34
纯度 99.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

12-lipoxygenase:0.013 μM|5-lipoxygenase:0.09 μM|15-lipoxygenase:0.5 μM

体外活性

2-TEDC exhibits potent inhibition against 5-, 12-, and 15-lipoxygenase, with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.[1]

溶解度

Ethanol:25 mM,DMSO:90.0 mg/mL (285.4 mM),Sonification is recommended.

参考文献

1.Cho H, et al. Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase. J Med Chem. 1991;34(4):1503-1505.
2.Ni N, et al. Singapore Grouper Iridovirus Disturbed Glycerophospholipids Homeostasis: Cytosolic Phospholipase A2 Was Essential for Virus Replication. Int J Mol Sci. 2021;22(22):12597.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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