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2-Deoxy-D-glucose

CAS号

154-17-6

分子式

C6H12O5

主要靶点

Hexokinase|Apoptosis|HSV

仅限科研使用

Cat No : CM00910

Print datasheet

Synonyms

Inhibitor|inhibit|NSC 15193|NSC15193|NSC-15193|2 Deoxy D glucose|2-DG|2-DG|2-DG|2DeoxyDglucose|2-Deoxy-D-glucose|2-deoxyglucose|2-Deoxy-D-arabino-hexose|2-脱氧-D-葡萄糖|Apoptosis|Ba 2758|D-Arabino-2-deoxyhexose|D-2-脱氧葡萄糖|Herpes simplex virus|Hexokinase|HSV

验证数据展示

  • CAS No.: 154-17-6

    2-Deoxy-D-glucose
    CAS#: 154-17-6

产品信息

CAS号 154-17-6
分子式 C6H12O5
主要靶点 Hexokinase|Apoptosis|HSV
主要通路 代谢|凋亡|微生物学
分子量 164.16
纯度 99.91%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|inhibit|NSC 15193|NSC15193|NSC-15193|2 Deoxy D glucose|2-DG|2-DG|2-DG|2DeoxyDglucose|2-Deoxy-D-glucose|2-deoxyglucose|2-Deoxy-D-arabino-hexose|2-脱氧-D-葡萄糖|Apoptosis|Ba 2758|D-Arabino-2-deoxyhexose|D-2-脱氧葡萄糖|Herpes simplex virus|Hexokinase|HSV

体内活性

方法：为研究对白细胞亚群分布和功能的影响，将 2-Deoxy-D-glucose (500-1500 mg/kg) 腹腔注射 BDF1 小鼠，注射一次或三次。 结果：一次注射高达 1500 mg/kg 的 2-Deoxy-D-glucose 的小鼠的血糖浓度呈剂量依赖性增加。在一次或三次注射高达 1500 mg/kg 的 2-Deoxy-D-glucose 后，皮质酮水平、脾脏中的白细胞计数和胸腺中的 CD3+ 细胞增加。2-Deoxy-D-glucose 给药诱导胸腺和脾细胞分布和功能的剂量依赖性变化。[3] 方法：为检测体内抗肿瘤活性，将 2-Deoxy-D-glucose (1000 mg/kg) 腹腔注射给携带黑色素瘤 B16 的 C57BL/6 小鼠，每天一次，持续八天。 结果：2-Deoxy-D-glucose 显著抑制肿瘤生长。TAMs 在 2-Deoxy-D-glucose 处理后显示Arg、Fizz、CD206 和 Vegf 表达显著降低。[4]

体外活性

方法：胰腺癌细胞 MIA PaCa2、BxPC-3、ASPC-1 和卵巢癌细胞 OVCAR-3、HEY、SK-OV-3 用 2-Deoxy-D-glucose (0.01-100 mM) 处理 48 h，使用 MTT 检测细胞增殖。 结果：2-Deoxy-D-glucose 对肿瘤细胞显示出显著的抗增殖活性，IC50 值在 1.45-13.34 mM 之间。[1] 方法：三阴性乳腺癌细胞 Hs578T 用 2-Deoxy-D-glucose (15? mM) 处理 24 天，使用 Migration assay 和 Invasion assay 检测细胞运动情况。 结果：2-Deoxy-D-glucose 抑制 Hs578T 细胞的迁移、侵袭。[2]

溶解度

H2O:100 mg/mL (609.16 mM);DMSO:60 mg/mL (365.5 mM)

细胞实验

2×103 H460 or H157 cells are seeded in 96-well cell culture plates. Cells are treated with 5 mM 2-DG only, 5 or 10 μM IGF1R inhibitor II only, or a combination of 2-DG and IGF1R inhibitor II. Cell growth inhibition is determined after 48 h by the CellTiter 96® AQueous nonradioactive cell proliferation assay. (Only for Reference)

参考文献

1.Malm SW, et al. The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines. J Exp Clin Cancer Res. 2015 Apr 1;34(1):31.
2.O'Neill S, et al. 2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype. Sci Rep. 2019 Mar 7;9(1):3788.
3.Dréau D, et al. Effects of 2-deoxy-D-glucose administration on immune parameters in mice. Immunopharmacology. 1998 Jun;39(3):201-13.
4.Zhao Q, et al. 2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation. Front Immunol. 2017 Jun 1;8:637.
5.Huang CC, et al. Dis Model Mech. 2015, 8(10):1247-54.

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