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1,4-DPCA

CAS号

331830-20-7

分子式

C13H8N2O3

主要靶点

HIF/HIF Prolyl-Hydroxylase

仅限科研使用

Cat No : CM16172

Print datasheet

Synonyms

P4HA1|P4HA2|P4HA3|inhibit|Inhibitor|wound|1,4DPCA|1,4-DPCA|1,4 DPCA|HIF-1α|HIFProlylHydroxylase|HIF-PH|HIFs|HIF|HIF Prolyl-Hydroxylase|HIF/HIF ProlylHydroxylase|HIF ProlylHydroxylase|HIF/HIF Prolyl-Hydroxylase|HIF/HIFProlylHydroxylase|healing|Hypoxia-inducible factors|FIH

验证数据展示

  • CAS No.: 331830-20-7

    1,4-DPCA
    CAS#: 331830-20-7

产品信息

CAS号 331830-20-7
分子式 C13H8N2O3
主要靶点 HIF/HIF Prolyl-Hydroxylase
主要通路 表观遗传|代谢
分子量 240.21
纯度 97.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 P4HA1|P4HA2|P4HA3|inhibit|Inhibitor|wound|1,4DPCA|1,4-DPCA|1,4 DPCA|HIF-1α|HIFProlylHydroxylase|HIF-PH|HIFs|HIF|HIF Prolyl-Hydroxylase|HIF/HIF ProlylHydroxylase|HIF ProlylHydroxylase|HIF/HIF Prolyl-Hydroxylase|HIF/HIFProlylHydroxylase|healing|Hypoxia-inducible factors|FIH

体内活性

在小鼠体内，1,4-DPCA有效抑制了盘内及其外表面的胶原蛋白沉积，并限制了结缔组织的生长。1,4-DPCA抑制了植入腹膜腔的多孔聚（乳酸-共-乙醇酸）盘中结缔组织的生长[3]。

体外活性

1,4-DPCA 显著降低了T4-2 (10 μM)和ZR-75-1细胞(20 μM)的集落大小和侵袭性分支。1,4-DPCA抑制了T4-2、ZR-75-1、MDA-MB-231细胞和MDA-MB-157[1]的增殖。在小鼠B6细胞中，1,4-DPCA特异性地增加了包括Hmox1和Vegfa在内的促血管生成目标基因的表达，以及包括Ldh-a、Pdk1、Glut1和Pgk1在内的促糖酵解目标的表达[2]。

溶解度

DMSO:2.78 mg/mL (11.56 mM)

参考文献

1.Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1.
2.Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92.
3.Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2