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(-)-p-Bromotetramisole Oxalate

(-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) 是一种强效的、非特异性碱性磷酸酶抑制剂。

CAS号

62284-79-1

分子式

C13H13BrN2O4S

主要靶点

Phosphatase|Phosphorylase

仅限科研使用

Cat No : CM05892

Print datasheet

Synonyms

L-p-Bromotetramisole oxalate|(-)-对溴四咪唑草酸盐|6-Bromolevamisole oxalate|(-)-p-Bromolevamisole oxalate

验证数据展示

  • CAS No.: 62284-79-1

    (-)-p-Bromotetramisole Oxalate
    CAS#: 62284-79-1

产品信息

p-Bromotetramisole Oxalate is a potent and non-specific inhibitor of alkaline phosphatase.

CAS号 62284-79-1
分子式 C13H13BrN2O4S
主要靶点 Phosphatase|Phosphorylase
主要通路 代谢
分子量 373.22
纯度 98.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 L-p-Bromotetramisole oxalate|(-)-对溴四咪唑草酸盐|6-Bromolevamisole oxalate|(-)-p-Bromolevamisole oxalate

体外活性

Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A. [1] In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. [2] In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. [3]

溶解度

DMSO:69 mg/mL (184.9 mM),H2O:28 mg/mL (75 mM),Ethanol:<1 mg/mL

参考文献

1.Onsgard-Meyer M,et al.Proc Soc Exp Biol Med. 1996 Nov;213(2):193-5.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2