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α-Vitamin E

CAS号

59-02-9

分子式

C29H50O2

主要靶点

Others|Endogenous Metabolite|Reactive Oxygen Species|Influenza Virus|Antibacterial|Ferroptosis|GST|PKC

仅限科研使用

Cat No : CM00571

Print datasheet

Synonyms

scavenger|SEC14-like protein|αVitamin E|α-Vitamin E|α-Tocopherol|α Vitamin E|VE|Vitamin E|天然维生素E|PKC|peroxyl|radical|Reactive Oxygen Species|ReactiveOxygenSpecies|D-alpha-Tocopherol|D-a-Tocopherol|D-α-Tocopherol|Endogenous Metabolite|EndogenousMetabolite|GSTP|GST Mu 3|GST omega-1|Ferroptosis|Influenza Virus|InfluenzaVirus|alpha-Vitamin E|Alpha-Tocopherol|5,7,8-Trimethyltocol|(+)-alpha-Tocopherol|Bacterial|a-Tocopherol|a-Vitamin E

验证数据展示

  • CAS No.: 59-02-9

    α-Vitamin E
    CAS#: 59-02-9

产品信息

CAS号 59-02-9
分子式 C29H50O2
主要靶点 Others|Endogenous Metabolite|Reactive Oxygen Species|Influenza Virus|Antibacterial|Ferroptosis|GST|PKC
主要通路 微生物学|代谢|表观遗传|细胞骨架|NF-κB 信号通路|代谢|免疫与炎症|微生物学|凋亡|氧化还原
分子量 430.71
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 scavenger|SEC14-like protein|αVitamin E|α-Vitamin E|α-Tocopherol|α Vitamin E|VE|Vitamin E|天然维生素E|PKC|peroxyl|radical|Reactive Oxygen Species|ReactiveOxygenSpecies|D-alpha-Tocopherol|D-a-Tocopherol|D-α-Tocopherol|Endogenous Metabolite|EndogenousMetabolite|GSTP|GST Mu 3|GST omega-1|Ferroptosis|Influenza Virus|InfluenzaVirus|alpha-Vitamin E|Alpha-Tocopherol|5,7,8-Trimethyltocol|(+)-alpha-Tocopherol|Bacterial|a-Tocopherol|a-Vitamin E

体内活性

Vitamin E 能够在体内诱导TC-1细胞坏死，并减少了携带TC-1肿瘤的小鼠的肿瘤体积。在TC-1肿瘤小鼠的肿瘤中，维生素E降低了髓系源抑制细胞(MDSCs)的数量，并增强了T细胞的积累[1]。

体外活性

vitamin E 能够在TC-1细胞中引发坏死，并对抗一氧化氮具有抗氧化效果[1]。

溶解度

Saline:25 mg/mL (58.04 mM); DMSO:12 mg/mL (27.86 mM);

细胞实验

For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I. (Only for Reference)

参考文献

1.Kang TH, et al. PLoS One. 2014, 9(7):e103562.
2.Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics[J]. ACS nano. 2018 Dec 26;12(12):12380-12392.

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