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α-Spinasterol

CAS号

481-18-5

分子式

C29H48O

主要靶点

COX|Antibacterial|TRP/TRPV Channel

仅限科研使用

Cat No : CM11417

Print datasheet

Synonyms

COX-1|COX-2|COX|Cyclooxygenase|HMG-CoA reductase|inhibit|Bacterial|alpha-Spinasterol|a-Spinasterol|Inhibitor|Transient receptor potential channels|TRP Channel|TRPChannel|TRPV Channel|TRPV1|TRPVChannel|菠甾醇|αSpinasterol|α-Spinasterol|Α-波菜甾醇|α Spinasterol

验证数据展示

  • CAS No.: 481-18-5

    α-Spinasterol
    CAS#: 481-18-5

产品信息

CAS号 481-18-5
分子式 C29H48O
主要靶点 COX|Antibacterial|TRP/TRPV Channel
主要通路 神经科学|免疫与炎症|微生物学|离子通道
分子量 412.69
纯度 99.58%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 COX-1|COX-2|COX|Cyclooxygenase|HMG-CoA reductase|inhibit|Bacterial|alpha-Spinasterol|a-Spinasterol|Inhibitor|Transient receptor potential channels|TRP Channel|TRPChannel|TRPV Channel|TRPV1|TRPVChannel|菠甾醇|αSpinasterol|α-Spinasterol|Α-波菜甾醇|α Spinasterol

靶点活性

COX-2:7.76 μM (IC50)|COX-1:16.17 μM (IC50)

体内活性

口服α-spinasterol可以减轻术后疼痛。无论是术前（切口前0.5小时）还是术后（切口后0.5小时）给药，均可减少受伤组织中的细胞浸润。α-Spinasterol还能够减轻部分坐骨神经结扎引起的机械性痛觉过敏和紫杉醇引起的机械性及寒冷痛觉过敏。此外，α-spinasterol抑制了COX-1和COX-2酶活性，但不改变动物体温。重要的是，α-spinasterol不影响自发或强迫的运动活动。进一步地，它不会引起胃部损伤或肝肾变化，也不改变小鼠大脑皮层和脊髓切片中的细胞活力。

溶解度

DMSO:insoluble;H2O:insoluble

参考文献

1.Indiara, Brusco, Camila, et al. α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice.[J]. British Journal of Pharmacology, 2017.

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