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(R)-(-)-Rolipram

CAS号

85416-75-7

分子式

C16H21NO3

主要靶点

Others|DNA-PK

仅限科研使用

Cat No : CM05772

Print datasheet

Synonyms

inhibit|DNAPK|(-)-Rolipram|(R)-Rolipram|(R) ( ) Rolipram|(R)()Rolipram|Phosphodiesterase (PDE)|Inhibitor|Rolipram

验证数据展示

  • CAS No.: 85416-75-7

    (R)-(-)-Rolipram
    CAS#: 85416-75-7

产品信息

CAS号 85416-75-7
分子式 C16H21NO3
主要靶点 Others|DNA-PK
主要通路 PI3K/Akt/mTOR 信号通路|DNA 损伤和修复
分子量 275.34
纯度 99.6%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|DNAPK|(-)-Rolipram|(R)-Rolipram|(R) ( ) Rolipram|(R)()Rolipram|Phosphodiesterase (PDE)|Inhibitor|Rolipram

体外活性

通过剂量依赖性降低(R)-(-)-rolipram对cAMP水解的作用，增强adenylyl cyclase激活剂forskolin对cAMP合成的促进作用，抑制caspase-1的切割和IL-1β的分泌[1]。

溶解度

DMSO:95 mg/mL (345.03 mM)

参考文献

1.Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2