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(R)-(-)-Rolipram

(R)-(-)-Rolipram ((-)-Rolipram) 是一种 PDE4 抑制剂 Rolipram 的 R-对映异构体。

CAS号

85416-75-7

分子式

C16H21NO3

主要靶点

Others|DNA-PK

仅限科研使用

Cat No : CM05772

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Synonyms

(R)-Rolipram|(-)-Rolipram

验证数据展示

  • CAS No.: 85416-75-7

    (R)-(-)-Rolipram
    CAS#: 85416-75-7

产品信息

(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.

CAS号 85416-75-7
分子式 C16H21NO3
主要靶点 Others|DNA-PK
主要通路 PI3K/Akt/mTOR信号通路|其他|DNA损伤和修复
分子量 275.34
纯度 99.60%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (R)-Rolipram|(-)-Rolipram

体外活性

The reduction of (R)-(-)-rolipram on cAMP hydrolysis and the increasement of adenylyl cyclase activator forskolin on cAMP synthesis in a dose-dependent manner inhibits caspase-1 cleavage and IL-1β secretion[1].

溶解度

DMSO:95 mg/mL (345.03 mM),Sonification is recommended.

参考文献

1.Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2