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(±)-Huperzine A

(±)-Huperzine A 是一种从中药中提取的活性石松属生物碱。 (±)-Huperzine A 是一种特异性和可逆的乙酰胆碱酯酶抑制剂，可用于治疗阿尔茨海默病的研究。

CAS号

120786-18-7

分子式

C15H18N2O

主要靶点

AChE

仅限科研使用

Cat No : CM11410

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Synonyms

验证数据展示

  • CAS No.: 120786-18-7

    (±)-Huperzine A
    CAS#: 120786-18-7

产品信息

(±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs. (±)-Huperzine A is a selective and reversible inhibitor of AChE and can be used in studies about the treatment of Alzheimer's disease.

CAS号 120786-18-7
分子式 C15H18N2O
主要靶点 AChE
主要通路 神经科学
分子量 242.32
纯度 98.14%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

(±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflammation-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway[1].

溶解度

DMSO:50 mg/mL (206.34 mM)

参考文献

1.Burshtein G, et al. Transepithelial Transport of a Natural Cholinesterase Inhibitor, Huperzine A, along the Gastrointestinal Tract: the Role of Ionization on Absorption Mechanism. Planta Med. 2013 Jan 23.
2.Ruan Q, Liu F, Gao Z, et al. The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats. Mech Ageing Dev. 2013 Jan 8. pii: S0047-6374(12)00182-0.
3.Zhang HY. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012 Sep;33(9):1170-5.
4.Wang J, Zhang HY, Tang XC. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15.
5.Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 5;470(1):6-9.

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