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(-)-Epicatechin

CAS号

490-46-0

分子式

C15H14O6

主要靶点

Endogenous Metabolite|COX|Ferroptosis

仅限科研使用

Cat No : CM00724

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Synonyms

Endogenous Metabolite|COX|Ferroptosis|EndogenousMetabolite|Epicatechol|Epicatechin|epi-Catechin|(-)-Epicatechol|L-Epicatechin|表儿茶素

验证数据展示

  • CAS No.: 490-46-0

    (-)-Epicatechin
    CAS#: 490-46-0

产品信息

CAS号 490-46-0
分子式 C15H14O6
主要靶点 Endogenous Metabolite|COX|Ferroptosis
主要通路 免疫与炎症|神经科学|代谢|凋亡
分子量 290.27
纯度 98.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Endogenous Metabolite|COX|Ferroptosis|EndogenousMetabolite|Epicatechol|Epicatechin|epi-Catechin|(-)-Epicatechol|L-Epicatechin|表儿茶素

靶点活性

COX-1:3.2 μM

体内活性

衰老对肌肉生长/分化的调节因子产生不良影响，适量摄入黄烷醇类化合物(-)-Epicatechin可以部分逆转这些变化。在老鼠中，随着年龄的增长，肌肉抑制素和衰老相关的β-半乳糖苷酶水平上升，而follistatin和Myf5的水平下降。(-)-Epicatechin能降低肌肉抑制素和β-半乳糖苷酶水平，并增加肌肉生长标志物的水平。在人类中，随着年龄的增加，肌肉抑制素和β-半乳糖苷酶水平上升，而follistatin、MyoD和myogenin的水平下降。连续7天使用(-)-Epicatechin治疗可以增加手握力和血浆follistatin/肌肉抑制素比率[1]。低剂量(-)-Epicatechin治疗显著增加骨骼肌毛细血管密度、线粒体生物发生以及氧化酶活性，这与安慰剂组相比，可减少肌肉疲劳并提高耐力。(-)-Epicatechin可能调节血管生成和抗血管生成因子之间的蛋白表达，如VEGF-A和TSP-1[3]。

体外活性

(-)-Epicatechin 刺激 Panc-1 细胞的线粒体呼吸和氧气消耗，但对人正常成纤维细胞没有影响。(-)-Epicatechin 提高了 Panc-1、U87 和 MIA PaCa-2 细胞对辐射的敏感性，平均辐射增强因子（REF）分别为 1.7、1.5 和 1.2。(-)-Epicatechin 对正常成纤维细胞的辐射敏感性没有增强作用，REF 为 0.9，表明其对癌细胞具有选择性。当与辐射结合使用时，(-)-Epicatechin 在癌细胞中增加了 Chk2 的磷酸化和 p21 的诱导，但在正常细胞中没有这种作用[2]。

溶解度

H2O:2.25 mg/mL (7.75 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:45 mg/mL (155.02 mM)

细胞实验

Panc-1 cells are seeded into T-150 flasks and on the next day, cells are treated with different concentrations of (-)-epicatechin for 1 h, then harvested and solubilized in 10 mM HEPES (pH 7.4), 40 mM KCl, 1%Tween-20, 1 μM oligomycin, 1 mM PMSF,10 mM KF, 2 mM EGTA, and 1 mM Na3VO4. COX activity is measured in the presence of 20 mM ascorbate and 200 μM substrate cytochrome c from cow heart.(Only for Reference)

参考文献

1.Gutierrez-Salmean G, et al. J Nutr Biochem. 2014, 25(1):91-4.
2.Elbaz HA, et al. PLoS One. 2014, 9(2):e88322.
3.Hüttemann M, et al. FASEB J. 2012, 26(4):1413-22.
4.Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051.
5.Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784.
6.Shim K S, Hwang Y H, Jang S A, et al.?. Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients. ?2020, 12(7): 1927.

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