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(-)-Epicatechin

(-)-Epicatechin is a polyphenolic flavonoid that can act as an inhibitor of COX-1 (IC50 = 3.2 μM) and has activities of antioxidant, lipid-lowering and hypoglycemic, prevent cardiovascular diseases. (−)-Epicatechin is a 2R,3R stereoisomer of catechin.

CAS号

490-46-0

分子式

C15H14O6

主要靶点

COX

仅限科研使用

Cat No : CM00724

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Synonyms

L-Epicatechin;(-)-Epicatechol;Epicatechin

验证数据展示

  • CAS No.: 490-46-0

    (-)-Epicatechin
    CAS#: 490-46-0

产品信息

(−)-Epicatechin, as a flavanols, is found as a natural product in cacao and cacao products, such as dark chocolate, and in green tea. (−)-Epicatechin potently reduced luciferase expression (EC50 of 20.5 nM) at 6 hours. Neurons were treated with (−)-epicatechin (100 nM for 6 hours), (−)-Epicatechin decreased Aβ1-40 levels by approximately 30%. In vivo, high-flavonoid dark chocolate containing 46 mg (−)-epicatechin daily for 2 weeks showed superior vascular function as seen by improved endothelium-dependent flow-mediated dilation of the brachial artery. Moreover, a reduction in ovalbumin-specific IgE present in the mice fed with the high dose (26 ± 13 ng/mL) and medium dose (89 ± 35 ng/mL) of (−)-epicatechin .

CAS号 490-46-0
分子式 C15H14O6
主要靶点 COX
主要通路 Natural Product
分子量 290.2681
MDL NO MFCD00075648
Pubchem ID 72276
纯度 97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名 L-Epicatechin;(-)-Epicatechol;Epicatechin

靶点

TargetActivity
COX1IC50=3.2μM

溶解度

DMSO57 mg/mL
WaterInsoluble
EthanolInsoluble

参考文献

1Gutierrez-Salmean G, Ciaraldi TP, et al. Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem. 2014 Jan;25(1):91-4.
2Huttemann M, Lee I, Malek MH. (-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining. FASEB J. 2012 Apr;26(4):1413-22.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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