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BCI

BCI ((E)-BCI) 是双重特异性磷酸酶的变构抑制剂。它特异性抑制 DUSP6和 DUSP1的 EC50分别为 13.3 和 8.0 μM，但不能够抑制 DUSP5。

CAS号

1245792-51-1

分子式

C22H23NO

主要靶点

Phosphatase

仅限科研使用

Cat No : CM05895

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Synonyms

(E)-BCI

验证数据展示

  • CAS No.: 1245792-51-1

    BCI
    CAS#: 1245792-51-1

产品信息

BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.

CAS号 1245792-51-1
分子式 C22H23NO
主要靶点 Phosphatase
主要通路 代谢
分子量 317.42
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (E)-BCI

溶解度

DMSO:125 mg/mL (393.80 mM),Sonification is recommended.

参考文献

1.Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2