Recombinant Human PIGR protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human PIGR protein Lys19-Arg638 (Accession# P01833) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 5284 |
| 蛋白编号 | P01833 |
| 预测分子量 | 93.4 kDa |
| SDS-PAGE | 90-125 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The polymeric immunoglobulin receptor (PIGR), an integral membrane protein, is required for transcytosis of polymeric immunoglobulins (pIg) including IgA and IgM across mucosal epithelial cells. PIGR is expressed on the basolateral surface of ciliated epithelial cells in the mucosal epithelium. Upregulation of pIgR expression has been well documented with a variety of proinflammatory cytokines such as IFN-γ and IL-1α.
参考文献:
1. Zhang, J R et al. Cell vol. 102,6 (2000): 827-37. 2. Turula H, Wobus CE. Viruses. (2018);10(5):237. 3. Wei H, Wang JY. Int J Mol Sci. (2021);22(5):2284.
