Recombinant Mouse TNFSF15 protein (rFc Tag)
种属
Mouse
纯度
>90?%, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90?%, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse TNFSF15 protein Ala61-Leu252 (Accession# Q5UBV8) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 326623 |
| 蛋白编号 | Q5UBV8 |
| 预测分子量 | 47.5 kDa |
| SDS-PAGE | 50-60 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) is also named as TL1 and VEGI. And it belongs to the tumor necrosis factor family. It is a receptor for TNFRSF25 and TNFRSF6B. VEGI induced degradation of IκB alpha, and nuclear translocation of p65 subunit of NFκB by activating NFκB. TL1A mediates activation and apoptosis of NFκB in DR3-expressing cell lines. Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression. The isoforms show endothelial cell-specific expression and are generated from a 17 kb human gene by alternative splicing. In addition, VEGI can inhibit vascular endothelial growth and angiogenesis (in vitro).
参考文献:
1. Haridas V. et al. (1999). Oncogene. 18(47):6496-504. 2. Migone TS. et al. (2002). Immunity. 16(3):479-92 3. Chew LJ. et al. (2002). FASEB J. 16(7):742-4. 4. Zhai Y. et al. (1999). FASEB J. 13(1):181-9.
