Recombinant Human Draxin protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Draxin protein Gly26-Val349 (Accession# Q8NBI3) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 374946 |
| 蛋白编号 | Q8NBI3 |
| 预测分子量 | 62.1 kDa |
| SDS-PAGE | 67-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
C1orf187, also named Draxin(Dorsal repulsive axon guidance protein), is a repulsive axon guidance cue. It is widely expressed in the developing hippocampus, glioma, and all histological types of the lung cancer cell. Draxin was shown to bind a 22-amino-acid peptide of the EGF domain of Netrin-1, and through Draxin/Netrin-1 interaction, Draxin may act as a secreted Netrin-1 antagonist. C1orf187 can inhibit or repel neurite outgrowth from dorsal spinal cord. It inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
参考文献:
1. Ahmed G, Shinmyo Y. (2021) Front Neuroanat. 15:766911. 2. Shinmyo Y. (2025) Front Cell Dev Biol. 13:1560940. 3. Liu Y, Hong W, Zhou Y, et al. (2025) Development. 152(20):dev204718. 4. Pałasz A, Suszka-Świtek A, Francikowski J, et al. (2021) Pharmaceuticals (Basel). 14(4):298.
