• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Human LILRB1/CD85j protein (rFc Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3701

Print datasheet

Synonyms

LILRB1, CD85, CD85 antigen-like family member J, CD85j, FLJ37515

验证数据展示

  • Purity of Recombinant Human LILRB1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human LILRB1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human LILRB1/CD85j was greater than 90% as determined by SEC-HPLC.

    The purity of Human LILRB1/CD85j was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human LILRB1 protein Gly24-His458 (Accession# Q8NHL6) with a rabbit IgG Fc tag at the C-terminus.
基因ID 10859
蛋白编号 Q8NHL6
预测分子量 73.5 kDa
SDS-PAGE 80-100 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

LILRB1 (Leukocyte Immunoglobulin-like Receptor B1), also known as CD85j, ILT, and MIR7, is a member of the immunoglobulin superfamily and is expressed in a wide variety of immune cells, including natural killer (NK) cells, monocytes, macrophages, and dendritic cells. LILRB1 acts as an immunosuppressive receptor functions and is involved in immunomodulation and regulation of immune response. Recently, HLA class I expression was shown to protect cancer cells from macrophage phagocytosis by interacting with LILRB1, making LILRB1 also a phagocytic checkpoint. LILRB1 is also a promising therapeutic target for patients with multiple myeloma.

参考文献:

1. Zeller T, et al. (2023). Front Immunol. 14:1240275.                                                   
2. Hu Z, et al. (2024). Front Immunol. 15:1421092.                                                         
3. Xian M, et al. (2024). Nat Commun. 15(1):5767.