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Recombinant Mouse Timd4 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3307

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Synonyms

SMUCKLER, Spleen, mucin-containing, knockout of lymphotoxin protein, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4

验证数据展示

  • Purity of Recombinant Mouse Timd4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Timd4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Timd4 protein Ala23-Thr279 (Accession# Q6U7R4) with a rabbit IgG Fc tag at the C-terminus.
基因ID 276891
蛋白编号 Q6U7R4
预测分子量 51.1 kDa
SDS-PAGE 72-95 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

T cell immunoglobulin mucin 4 (Tim4), a macrophage receptor for phosphatidylserine (PtdSer) on apoptotic cells. It is evidenced that TIMD-4 as phosphatidylserine (PS) receptor is capable of maintaining peritoneal macrophages’ homeostatic function and regulating adaptive immunity based on the alteration of Ag-particular T cells’ clearance. It is noteworthy that TIMD-4’s dysregulating process was identified under several autoimmune states, in particular inside immune cells. In addition, TIMD-4 was identified to be over-expressed in Systemic lupus erythematosus (SLE) cases.

参考文献:

1. Kuroiwa Miki, et al. (2023) Sci Total Environ. 875 : 162586.
2.Yang Zhicheng, et al. (2021) Pharmgenomics Pers Med.14:221-228.