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Recombinant Mouse SOST/Sclerostin protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3294

Print datasheet

Synonyms

Sclerostin, Sost, SOST/Sclerostin

验证数据展示

  • Purity of Recombinant Mouse SOST was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse SOST was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse SOST protein Gln24-Tyr211 (Accession# Q99P68) with a rabbit IgG Fc tag at the N-terminus.
基因ID 74499
蛋白编号 Q99P68
预测分子量 48.3 kDa
SDS-PAGE 50-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Sclerostin (Sost) is a potent negative regulator of bone mass, where it normally inhibits Wnt signaling through interactions with low‐density lipoprotein receptor‐related protein (LRP) 5/6 co‐receptors. Expression of the gene product sclerostin in bone is restricted to osteocytes. In the absence of Sost protein, patients develop two types of hyperostosis, sclerosteosis and van Buchem disease. Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation. Sclerosteosis is associated with mutations in the SOST gene and Van Buchem disease with a 52 kb deletion downstream of the SOST gene that probably affects transcription of the gene.

参考文献:

1.van Bezooijen, et al. (2005) Biochemistry.16(3):319-327. 
2.Chang Jiun C, et al. (2018) Biochemistry.33(6):1105-1113. 
3.Sun Lisha, et al. (2022) Biochemistry.21(1):228.