Recombinant Mouse IL-12 R beta 1 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IL-12 R beta 1 protein Gln20-Ser565 (Accession# Q60837) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 16161 |
| 蛋白编号 | Q60837 |
| 预测分子量 | 87.4 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL-12RB1 (Interleukin-12 receptor subunit beta-1) is a type I transmembrane receptor that can bind to the P40 domain of IL-12/IL-23 and promote their immune response separately. Meanwhile, excess P40 binding to IL-12RB1 reduces the antitumor effect of normal IL-12, resulting in immune evasion of the tumor cells. IL-12RB1 was mainly expressed in epithelial cells and immune cells. IL-12RB1 was tightly associated with PD-1/PD-L1 expression and may have a potential effect on treatments targeting the PD-1/PD-L1 axis.
参考文献:
1. Vignali, Dario A A, and Vijay K Kuchroo. Nature immunology vol. 13,8 (2012) 722-8. 2. Kundu, Madhuchhanda et al. Proceedings of the National Academy of Sciences of the United States of America vol. 114,43 (2017): 11482-11487. 3. Chen, Zheng et al. Annals of translational medicine vol. 10,3 (2022): 144.
