Recombinant Mouse MMP8 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse MMP8 protein Phe21-Ser465 (Accession# O70138) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 17394 |
| 蛋白编号 | O70138 |
| 预测分子量 | 76.4 kDa |
| SDS-PAGE | 80-90 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Matrix Metalloproteinase 8 (MMP8), also known as neutrophil collagenase, is a member of the MMP family that plays a critical role in extracellular matrix remodeling. It is primarily expressed in neutrophils and is involved in collagen degradation and tissue repair. MMP8 has been shown to facilitate neutrophil migration and is essential for immune responses. In cancer, MMP8 can have both pro-tumorigenic and anti-tumorigenic roles. For instance, mutations in MMP8 have been identified in melanoma, with wild-type MMP8 inhibiting tumor progression. Additionally, MMP8-deficient mice exhibit increased susceptibility to certain infections and delayed wound healing. These findings highlight the multifaceted role of MMP8 in inflammation, cancer, and tissue repair.
参考文献:
1. Lin, Michelle et al. The American journal of pathology vol. 173,1 (2008): 144-53. 2. Palavalli, Lavanya H et al. Nature genetics vol. 41,5 (2009): 518-20. 3. Daly, Meghan C et al. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 30,10 (2016): 3453-3460.
