Recombinant Human LAG-3/CD223protein (Myc Tag, His Tag)
种属
Human
纯度
>85 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >85 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human LAG-3 protein Leu23-Leu450 (Accession# P18627-1) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 3902 |
| 蛋白编号 | P18627-1 |
| 预测分子量 | 51.8 kDa |
| SDS-PAGE | 58-68 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function.
参考文献:
1. Workman, Creg J, and Dario A A Vignali. Journal of immunology (Baltimore, Md. : 1950) vol. 174,2 (2005): 688-95. 2. Goldberg, Monica V, and Charles G Drake. Current topics in microbiology and immunology vol. 344 (2011): 269-78. 3. Zhang, Qianxia et al. Science immunology vol. 2,9 (2017): eaah4569.
