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Recombinant Mouse IL-13RA2 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3118

Print datasheet

Synonyms

CD213a2, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, Il13ra2, IL-13R-alpha-2

验证数据展示

  • Purity of Recombinant Mouse IL-13RA2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse IL-13RA2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse IL-13RA2 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse IL-13RA2 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse IL-13RA2 protein Leu22-Lys334 (Accession# O88786-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 16165
蛋白编号 O88786-1
预测分子量 62.5 kDa
SDS-PAGE 68-80 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

The protein encoded by the Il13ra2 gene is closely related to Il13ra1, a subunit of the interleukin 13 receptor complex. This protein binds IL13 with high affinity but lacks a cytoplasmic domain and does not function as a signal mediator. It is reported to play a role in the internalization of IL13. It acts as a decoy receptor for IL-13, diminishing its STAT6-mediated effector functions. It has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Mouse models have been used to study the function of Il13ra2 in IBD, and its human ortholog IL13RA2 is a promising candidate for the development of therapeutic strategies for IBD.

参考文献:

1. Seblani M, Zannikou M, et al. (2024) Res Sq. rs.3.rs-5398280. 
2. Zhang T, Zhu M, et al. (2024) J Adv Res. S2090-1232(24)00082-1. 
3. Marquardt RM, Lee K, et al. (2020) Biol Reprod. 103(4):760-768. 
4. Saka M, Amano T, et al. (2010) J Neurosurg. 113(2):270-9.