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Recombinant Human Alpha 2-Antiplasmin protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3041

Print datasheet

Synonyms

Alpha-2-antiplasmin, Serpin F2, a2-antiplasmin, A2AP, AAP

验证数据展示

  • Purity of Recombinant Human Alpha 2-Antiplasmin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Alpha 2-Antiplasmin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Alpha 2-Antiplasmin protein Met28-Lys491 (Accession# P08697-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 5345
蛋白编号 P08697-1
预测分子量 77.8 kDa
SDS-PAGE 80-95 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

SERPINF2 (Serpin Family F Member 2), also known as alpha-2-antifibrinolysis (alpha-2 antiplasmin, AAP), is a member of the serine protease inhibitor (Serpin) superfamily. This protein is a major inhibitor of fibrinolytic enzymes, which degrade fibronectin and various other proteins. Thus, SERPINF2 has an important role in the regulation of the blood coagulation pathway. Mutations in SERPINF2 can lead to alpha-2-fibrinolytic inhibitor deficiency, which is characterized by a severe bleeding tendency and is associated with the development of a variety of diseases including cardiovascular disease, thrombosis, and certain inflammatory disorders.

参考文献:

1.Onishi S, et al. iScience. 2023;26(8):107271.                                                             
2. Kyung N. Lee, et al. Blood 2004; 103 (10): 3783–3788.                                       
3. Shao X, et al. J Hypertens. 2019;37(1):197-205.                                                    
4. Viganò S, et al. Thromb Res. 2018;166:60-62.