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Recombinant Mouse Ccl11 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2400

Print datasheet

Synonyms

C-C motif chemokine 11, Eosinophil chemotactic protein, Eotaxin, Scya11, Small-inducible cytokine A11

验证数据展示

  • Purity of Recombinant Mouse Ccl11 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Ccl11 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Ccl11 protein His24-Pro97 (Accession# P48298) with a rabbit IgG Fc tag at the N-terminus.
基因ID 20292
蛋白编号 P48298
预测分子量 35.2 kDa
SDS-PAGE 37-45 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CCL11 also named Eotaxin, was initially discovered as an eosinophil-specific chemoattractant. CCL11 plays a central role in both allergic and non-allergic inflammatory reactions by recruiting immune cells such as eosinophils,basophils and Th2 lymphocytes. CCL11 binds to the chemokine receptors CCR2, CCR3 and CCR5, with highest affinity to CCR3. High levels of CCL11 have been described in several chronic inflammatory diseases, such as allergic rhinitis, atopic dermatitis, asthma, gastrointestinal disease and rheumatoid arthritis.

参考文献:

1. Garcia-Zepeda EA. et al. (2019) Nat Med. 2(4):449-56.
2. Ye J. et al. (2000) J Biol Chem.275(35):27250-7.
3. Kitaura M. et al. (1996) J Biol Chem. 271(13):7725-30.
4. Kokkonen H. et al. (2010) Arthritis Rheum. 62(2):383-91.
5. Clin Immunol.et al. (2014) Clin Immunol. 153(1):199-208.
6. Wu D. et al. (2019) J Asthma.51(8):847-54.
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