Recombinant Mouse CD268/BAFF-R protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD268 protein Ser10-Ala71 (Accession# Q9D8D0-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 72049 |
| 蛋白编号 | Q9D8D0-1 |
| 预测分子量 | 33.0 kDa |
| SDS-PAGE | 37-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells. The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation. Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells.
参考文献:
1. Zhou, Xiaolan et al. Frontiers in oncology vol. 10 682. 27 May (2020). 2. Smulski, Cristian R, and Hermann Eibel. Frontiers in immunology vol. 9 2285. 8 Oct (2018). 3. Möckel, Tamara et al. International journal of molecular sciences vol. 25,10 5415. 16 May (2024).
