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Recombinant Human DDR1 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1675

Print datasheet

Synonyms

CAK, CD167, CD167 antigen-like family member A, CD167a, Cell adhesion kinase

验证数据展示

  • Purity of Recombinant Human DDR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human DDR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human DDR1 protein Asp21-Thr416 (Accession# Q08345-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 780
蛋白编号 Q08345-1
预测分子量 70.2 kDa
SDS-PAGE 70-90 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

DDR1, or Discoidin Domain Receptor 1, is a member of the receptor tyrosine kinase (RTK) family, which plays a significant role in various cellular processes including cell proliferation, adhesion, migration, and extracellular matrix (ECM) remodeling. DDR1 is known for its unique discoidin domain that allows it to bind specifically to certain collagens, initiating downstream signaling pathways that can lead to cell transformation and tumor progression (PMID: 38580164). Abnormal activation of DDR1 is closely associated with the development of various solid tumors. It mediates various signal pathways to stimulate cancer cell invasion, migration, and drug resistance. The extracellular domain of DDR1 enhances the tumor microenvironment by inhibiting tumor T-cell infiltration and promoting tumor growth.

参考文献:

1. Wu D. et al. (2024). Drug Discov Today. 29(5):103975.
2. Liu M. et al. (2024). Eur J Med Chem. 268:116291.
3. Yang L. et al. (2023). Sci Rep. 13(1):5779.