Recombinant Human GPR132 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human GPR132 protein Met1-Leu45 (Accession# Q9UNW8) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 29933 |
| 蛋白编号 | Q9UNW8 |
| 预测分子量 | 31.1 kDa |
| SDS-PAGE | 35-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
GPR132, which stands for G Protein-Coupled Receptor 132, is an important seven-transmembrane domain protein. It is primarily expressed in immune cells such as macrophages and functions as a sensor for microenvironmental signals, capable of specifically recognizing ligands like protons (H⁺) and oxidized lipids (e.g., 5-oxo-ETE). Its core role lies in connecting metabolism with immunity: in acidic tumor microenvironments or atherosclerotic plaques, GPR132 activation drives macrophages toward a pro-tumor or pro-inflammatory M2 phenotype, thereby promoting disease progression. Strong preclinical evidence indicates that inhibiting GPR132 can remodel the immune microenvironment and effectively suppress tumor growth and metastasis. As a result, GPR132 is regarded as a highly promising therapeutic target, particularly in the fields of cancer immunology and inflammatory diseases.
参考文献:
1. Wang, Jia-Le et al. Nature metabolism vol. 5,10 (2023): 1726-1746. 2. Hui, Xinhui et al. Science advances vol. 11,10 (2025): eadr9395. 3. Chen, Peiwen et al. Proceedings of the National Academy of Sciences of the United States of America vol. 114,3 (2017): 580-585. 4. Liu, Ye et al. Cancer cell international vol. 23,1 253. 27 Oct. 2023.
