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Recombinant Mouse OX40L/TNFSF4 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1573

Print datasheet

Synonyms

CD252, OX40 ligand, OX40L, Tnfsf4, Tumor necrosis factor ligand superfamily member 4

验证数据展示

  • Purity of Recombinant Mouse OX40L was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse OX40L was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse OX40L protein Ser51-Leu198 (Accession# P43488) with a rabbit IgG Fc tag at the N-terminus.
基因ID 22164
蛋白编号 P43488
预测分子量 43.7 kDa
SDS-PAGE 45-55 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

The OX40 ligand (OX40L) is also named as TNFSF4, CD252, Glycoprotein Gp34 and TXGP1. It belongs to the tumor necrosis factor family. OX40L is a costimulatory molecules that is mainly expressed on APCs, including mature DCs, B cells, and macrophages. OX40L interacts with OX40 (also CD134) that is preferentially expressed on activated CD4 T cells. OX40L expression in DCs is up-regulated by several stimulatory signalings, including thymic stromal lymphopoietin (TSLP), CD40, PAMPs, and IFN-α. Of note, IgE-Ag complex-activated mast cells up-regulate the expression of OX40L, and interactions between OX40L on mast cells and OX40 on T cells is required for T cell proliferation.

参考文献:

1.Sugamura K. et al. (2004) Nat Rev Immunol. 4(6):420-31.
2.Yashiro T. et al. (2016) Sci Rep. 6:34825.
3.Kurche JS. et al. (2012) J Immunol. 188(2):585-93. 
4.Ito T. et al. (2005) J Exp Med. 202(9):1213-23.
5.Nakae S. et al. (2006) J Immunol. 176(4):2238-48.