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Recombinant Human CLEC9A protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1444

Print datasheet

Synonyms

CD370, C-type lectin domain family 9 member A, DNGR1, UNQ9341, UNQ9341/PRO34046

验证数据展示

  • Purity of Recombinant Human CLEC9A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CLEC9A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CLEC9A protein Lys57-Val241 (Accession# Q6UXN8) with a rabbit IgG Fc tag at the N-terminus.
基因ID 283420
蛋白编号 Q6UXN8
预测分子量 48.4 kDa
SDS-PAGE 52-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CLEC9A (C-type lectin domain family 9 member A), also known as DNGR1, CD370, is a type II membrane protein that contains C-type lectin domain. The C-type lectin domain family members share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. Mouse Clec9A is primarily restricted to dendritic cells (DCs) and selectively expressed in mouse CD8+ conventional DCs (cDCs) and plasmacytoid DCs (pDCs), whereas human CLEC9A is also expressed on human DC subtypes. CLEC9A functions as an activating receptor that recruits Syk kinase and can induce the production of proinflammatory cytokines.

参考文献:

1. Dambuza IM, et al. (2015). Curr Opin Immunol. 32:21-7.
2. McGreal EP, et al. (2004). Mol Immunol. 41(11):1109-21.
3. Caminschi I, et al. ( 2008). Blood. 112(8):3264-73.
4. Huysamen C, et al. (2008). J Biol Chem. 283(24):16693-701.