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Recombinant Mouse Transferrin protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1066

Print datasheet

Synonyms

Beta-1 metal-binding globulin, Serotransferrin, Siderophilin, Tf, Trf

验证数据展示

  • Purity of Recombinant Mouse Transferrin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Transferrin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Transferrin protein Val20-His697 (Accession# Q921I1) with a His tag at the C-terminus.
基因ID 22041
蛋白编号 Q921I1
预测分子量 76.0 kDa
SDS-PAGE 65-80 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Transferrin, also known as Trf, is a crucial iron-binding transport protein. It plays a vital role in iron homeostasis by binding and transporting iron throughout the body, particularly from the sites of absorption to the sites of storage and utilization. Transferrin is primarily synthesized by the liver. It can bind two ferric iron (Fe3+) ions, each associated with a bicarbonate anion, which helps maintain iron in a soluble form and minimizes its redox activity. Transferrin also interacts with clotting factors and plays a central role in coagulation balance. It has been shown to potentiate the enzymatic activity of thrombin and FXIIa and inhibit antithrombin (AT) independently of iron. Elevated levels of transferrin have been associated with atherosclerosis, and it has been found in increased amounts in the plasma of mice fed a high-fat diet, which correlates with atherosclerotic plaque development.

参考文献:

1. Julia T Bu. et al. (2015). Biometals. 28(3):473-480.
2. Xiaopeng Tang. et al.(2020). Cell Res. 30(2):119-132.
3. Konstantinos Gkouvatsos. et al. (2012). Biochim Biophys Acta. 1820(3):188-202.