Recombinant Mouse Transferrin R protein (His tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Transferrin R protein Cys89-Phe763 (Accession# Q62351) with a His tag at the N-terminus. |
| 基因ID | 22042 |
| 蛋白编号 | Q62351 |
| 预测分子量 | 77.0 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD71, also known as transferrin receptor protein 1 (TfR1) is a type II cell membrane-associated glycoprotein involved in iron homeostasis and cell growth. CD71 is commonly upregulated in cells with high proliferative index, including cancer cells that need iron as cofactor of many enzymatic reactions, such as DNA synthesis. CD71 overexpression has been reported in several human malignant tumors, including lymphomas, carcinomas, neuroendocrine, and brain tumors.
参考文献:
1. Daniels, Tracy R et al. Biochimica et biophysica acta vol. 1820,3 (2012): 291-317. 2. Daniels, Tracy R et al. Clinical immunology (Orlando, Fla.) vol. 121,2 (2006): 159-76. 3. Pantopoulos, Kostas. Annals of the New York Academy of Sciences vol. 1012 (2004): 1-13.