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Recombinant Human FGFR3(IIIb) protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1041

Print datasheet

Synonyms

FGFR3, ACH, CD333, CEK2, FGFR 3

验证数据展示

  • Purity of Recombinant Human FGFR3(IIIb) was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human FGFR3(IIIb) was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human FGFR3(IIIb) protein Glu23-Gly377 (Accession# P22607-2) with a His tag at the C-terminus.
基因ID 2261
蛋白编号 P22607-2
预测分子量 39.4 kDa
SDS-PAGE 50-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Fibroblast growth factors (FGFs) are polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. The human FGF receptor family, a subfamily of receptor tyrosine kinases (RTKs), comprises of four family members-FGFR1, FGFR2, FGFR3, and FGFR4. Each receptor contains an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 plays a key role in different important physiological cellular processes such as regulation of cell growth, proliferation, angiogenesis, among the others. Moreover, FGFR3 binds acidic and basic fibroblast GH and plays a role in bone development and maintenance. Mutations in the FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia.

参考文献:

1. K Keegan. et al. (1991). Proc Natl Acad Sci U S A. 88(4):1095-9.
2. Kai Hung Tiong. et al. (2013).  Apoptosis.18(12):1447-1468.
3. C Deng. et al. (1996). Cell.84(6):911-921.
4. Claudia Maria Ascione. et al. (2023). Cancer Treat Rev.115:102530.