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Recombinant Mouse ANGPTL3 protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0662

Print datasheet

Synonyms

Angiopoietin-like 3/ANGPTL3, angiopoietin like 3

验证数据展示

  • Purity of Recombinant Human ANGPTL3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ANGPTL3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse ANGPTL3 protein Ser17-Thr455 (Accession# Q9R182) with a His tag at the C-terminus.
基因ID 30924
蛋白编号 Q9R182
预测分子量 52.3 kDa
SDS-PAGE 60-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ANGPTL3 belongs to the angiopoietin-like protein family. ANGPTL3 is mainly synthesized by liver cells and is notably expressed in kidney podocytes. Accumulating evidences have revealed that ANGPTL3 plays a critical role in both biological processes, such as lipid metabolism, angiogenesis and haematopoietic function and pathological changes, including atherosclerosis, carcinogenesis, nephrotic syndrome, diabetes, liver diseases and so on. Thus, ANGPTL3 may serve as a potential biomarker in these diseases. Overexpression of Angptl3 or intravenous injection of the purified protein in KK/San mice elicited a marked increase in circulating plasma lipid levels. It suggests that Angptl3 regulates lipid metabolism in mice.

参考文献:

1.Pei-Yi Chen. et al. (2021) Int J Mol Sci. 7;22(14):7310.
2.Shuang Jiang.et al. (2019) J Drug Target.27(8):876-884.
3.Ryuta Koishi. et al. (2002) Nat Genet.30(2):151-7.
4.Anna Tikka. et al. (2016) Endocrine. 52(2):187-93.