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Recombinant Human CSPG4 protein (Myc Tag, His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

Myc Tag, His Tag

生物活性

未测试

Cat no : Eg0201

Print datasheet

Synonyms

CSPG4, NG2, CSPG4,NG2, MCSP, MCSPG

验证数据展示

  • Purity of Recombinant Human CSPG4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CSPG4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CSPG4 protein Ser1583-Ser2224 (Accession# Q6UVK1) with a Myc tag and a His tag at the C-terminus.
基因ID 1464
蛋白编号 Q6UVK1
预测分子量 73.2 kDa
SDS-PAGE 90-125 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CSPG4, also named as HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16 and NG2, is a proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. CSPG4 may inhibit neurite outgrowth and growth cone collapse during axon regeneration. It is cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. CSPG4 is also a signal-transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. It is a target of specific diagnosis and immunotherapy with antiidiotypic antibodies due, in part, to its roles in growth control, adhesion, cell-substratum interactions, and cell-cell contacts.

参考文献:

1. Matthew A Price, et al. (2011) Pigment Cell Melanoma Res. 24(6):1148-57.
2. J Iida, et al. (2001) J Biol Chem. 276(22):18786-94.
3. Jianbo Yang, et al. (2004) J Cell Biol. 165(6):881-91.
4. K M Eisenmann, et al. (1999) Nat Cell Biol. 1(8):507-13.
5. Valeria Rolih, et al. (2017) J Transl Med. 15(1):151.