Recombinant Human FGFR2(IIIb) protein (hFc Tag, Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
hFc Tag, Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human FGFR2(IIIb) protein Arg22-Glu378 (Accession# P21802-3) with a human IgG1 Fc tag, a Myc tag and a His tag at the C-terminus. |
| 基因ID | 2263 |
| 蛋白编号 | P21802-3 |
| 预测分子量 | 71.1 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
FGFR2 (Fibroblast growth factor receptor 2) is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. This polyclonal antibody raised against 358-704aa of human FGFR2 can cross-react with other members of the FGFR family.
参考文献:
1. Vogel, Arndt et al. Annual review of medicine vol. 74 (2023): 293-306. 2. Goyal, Lipika et al. The New England journal of medicine vol. 388,3 (2023): 228-239. 3. Subbiah, Vivek et al. Cancer discovery vol. 13,9 (2023): 2012-2031. 4. Zingg, Daniel et al. Nature vol. 608,7923 (2022): 609-617.