Recombinant Human CD200R1 protein (Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD200R1 protein Ala27- Leu266(Accession# Q8TD46-4) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 131450 |
| 蛋白编号 | Q8TD46-4 |
| 预测分子量 | 32.4 kDa |
| SDS-PAGE | 45-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Cell surface glycoprotein CD200 receptor 1 (CD200R1) is also named as CD200R, CRTR2, MOX2R and OX2R, and belongs to the CD200R family. CD200R1 is inhibitory receptor for the CD200/OX2 cell surface glycoprotein. CD200R1 is highly glycosylated, containing ten potential N-glycosylation sites. CD200R1 limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. As an immune inhibitory molecule, CD200R1 binds to CD200, ultimately leading to inhibition of classical activation of macrophages and microglia.
参考文献:
1. Gorczynski, Reginald et al. Journal of immunology (Baltimore, Md. : 1950) vol. 172,12 (2004): 7744-9. 2. Hernangómez, Miriam et al. Current pharmaceutical design vol. 20,29 (2014): 4707-22.
