Validation Data Gallery
Technical Specifications
| GeneID | 2323 |
| Species | Human |
| Expression | HEK293 |
| Activity | 0.4-3.0 ng/mL |
| Specific Activity | minimally 5.00 x 105 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P49771 |
| Molecular Mass | 27 to 34 kDa reduced, 23 to 30 kDa non-reduced, monomer, glycosylated |
| Formulation | 1x PBS, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile water containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
FMS-related tyrosine kinase 3 ligand (FLT3 Ligand) is a growth factor that regulates proliferation of early hematopoietic cells. FLT3 Ligand binds to cells expressing the tyrosine kinase receptor FLT3. FLT3 Ligand by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation (PMID: 8590775; 7544638; 12176867).
Synonyms
FL, Flt3 ligand, Flt3L, FLT3LG, SL cytokine
Publications
| Species | Title |
|---|---|
Cell Res Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. | |
Blood LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. | |
Nat Commun α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron-microglia communication. | |
Dev Cell Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus | |
Haematologica CD123 expression patterns and selective targeting with a CD123-specific antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia. |
