ChromoTek TIM3 VHH, recombinant binding protein
Alpaca anti-TIM3 VHH, purified recombinant binding protein. Suitable for conjugation of dyes, biotin, beads, surfaces, etc. via NHS ester reaction
Specificity/Target
TIM3-Tag
Applications
Conjugation
Type
Nanobody
Conjugate
Unconjugated
Cat No : tmtCys
Synonyms
Validation Data Gallery
Product Information
Alpaca anti-TIM3 VHH, purified recombinant binding protein. Suitable for conjugation of dyes, biotin, beads, surfaces, etc. via NHS ester reaction
Applications | Conjugation |
Reactivity | Human |
Conjugate | Unconjugated |
Type | Nanobody |
Class | Recombinant |
Host | Alpaca |
Affinity | in the picomolar range, below the assay limit (biolayer interferometry) |
Molecular Weight | 14.824 kDa |
RRID | / |
Storage Buffer | 10 mM HEPES, 500 mM NaCl, pH 7.0, 1 mM TCEP |
Storage Condition | Store at -20°C; Shipped at dry ice. |
Background | TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3 (PMID: 20107545; 17069754; 11725301). |
Documentation
SDS |
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TIM3 VHH, recombinant binding protein SDS (PDF) |