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KPT185

化合物KPT-185

CAS号

1333151-73-7

分子式

C16H16F3N3O3

主要靶点

CRM1

仅限科研使用

Cat No : CM08749

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Synonyms

KPT-185|KPT 185

验证数据展示

  • CAS No.: 1333151-73-7

    KPT185
    CAS#: 1333151-73-7

产品信息

KPT-185 is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

CAS号 1333151-73-7
分子式 C16H16F3N3O3
主要靶点 CRM1
主要通路 离子通道
分子量 355.31
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 2 years
别名 KPT-185|KPT 185

靶点活性

CRM1:100-500nM

体内活性

在白血病细胞中（IC50=100 nM-500 nM）,KPT-185显着抑制细胞增殖。在AML细胞系和原发性AML母细胞中,KPT-185能够使细胞周期停滞,并诱导细胞凋亡。对于胰腺癌细胞,KPT-185抑制细胞的增殖,诱导细胞凋亡,但KPT-185不会影响人胰腺导管上皮细胞的生长。

溶解度

DMSO:66 mg/mL (185.8 mM),Ethanol:66 mg/mL (185.8 mM),H2O:<1 mg/mL

细胞实验

Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2