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CTPI-2

CAS号

68003-38-3

分子式

C13H9ClN2O6S

主要靶点

Mitochondrial Metabolism|Others

仅限科研使用

Cat No : CM06462

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Synonyms

CTPI 2|CTPI2|CTPI-2|glucose|inflammatory|carrier|citrate|NSCLC|mitochondrial|MitochondrialMetabolism|Mitochondrial Metabolism|macrophage|Inhibitor|inhibit|SLC25A1|steatohepatitis|steatosis|transporter

验证数据展示

  • CAS No.: 68003-38-3

    CTPI-2
    CAS#: 68003-38-3

产品信息

CAS号 68003-38-3
分子式 C13H9ClN2O6S
主要靶点 Mitochondrial Metabolism|Others
主要通路 代谢
分子量 356.74
纯度 97.23%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 CTPI 2|CTPI2|CTPI-2|glucose|inflammatory|carrier|citrate|NSCLC|mitochondrial|MitochondrialMetabolism|Mitochondrial Metabolism|macrophage|Inhibitor|inhibit|SLC25A1|steatohepatitis|steatosis|transporter

靶点活性

SLC25A1:3.5 μM (KD)

体内活性

CTPI-2通过逆转非酒精性脂肪性肝炎(NASH)相关的显著变化并阻止其发展为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，同时显著减轻高脂饮食引起的肥胖。这些效应通过全身性删除一个Slc25a1基因拷贝或特定于肝脏的Slc25a1基因敲除不同地重现，揭示了该蛋白剂量依赖性和组织特异性功能。机制上，通过依赖柠檬酸的活动，Slc25a1的抑制重新配置了脂肪生成程序，抑制了过氧化物酶体增殖活化受体γ的信号传导，后者是葡萄糖和脂质代谢的关键调节因子，并抑制了糖异生基因的表达。这些活动的结合不仅抑制了脂质合成过程，还正常化了高血糖和葡萄糖耐受不良。

溶解度

DMSO:30 mg/mL (84.09 mM)

参考文献

1.Tan M, et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020;27(7):2143-2157.
2.Peng R , Zhang M , Wang H , et al. Advances into Understanding the Vital Role of the Mitochondrial Citrate Carrier (CIC) in Metabolic Diseases, A Review[J]. Pharmacological Research, 2020:105132.

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