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  • KD/KO Validated

Chemerin Polyclonal antibody

Chemerin Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, Mouse and More (1)

Applications

IHC, WB, ELISA

Conjugate

Unconjugated

Cat No : 10216-1-AP

Print datasheet

Synonyms

Chemerin, HP10433, RAR responsive protein TIG2, RARRES2, TIG2



经过测试的应用

Positive WB detected inhuman plasma tissue
Positive IHC detected inhuman placenta tissue, mouse liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Chemerin has low expression in most cells and tissues

Planning an IHC experiment? We recommend our IHCeasy RARRES2 Ready-To-Use IHC Kit. RARRES2 primary antibody included.

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

10216-1-AP targets Chemerin in WB, IHC, ELISA applications and shows reactivity with human, Mouse samples.

Tested Applications IHC, WB, ELISA
Cited Applications IHC, WB
Tested Reactivity human, Mouse
Cited Reactivityhuman, mouse
Immunogen Chemerin fusion protein Ag0261 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name retinoic acid receptor responder (tazarotene induced) 2
Synonyms Chemerin, HP10433, RAR responsive protein TIG2, RARRES2, TIG2
Calculated Molecular Weight 163 aa, 19 kDa
Observed Molecular Weight 14-19 kDa
GenBank Accession NumberBC000069
Gene Symbol RARRES2
Gene ID (NCBI) 5919
RRIDAB_2269231
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ99969
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Chemerin, also named as TIG2 and RARRES2, is adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). It positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. RARRES2 have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. The MW of Chemerin is 14-19 kDa.

实验方案

Product Specific Protocols
WB protocol for Chemerin antibody 10216-1-APDownload protocol
IHC protocol for Chemerin antibody 10216-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouse,humanIHC,WB

Mil Med Res

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

Authors - Yi-Qun Li
humanWB

Cancer Cell Int

Targeting copper death genotyping associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration

Authors - Tao Yan
human,mouseWB,IHC

Front Pharmacol

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression

Authors - Ming Yu
  • KO Validated
humanIHC

Front Oncol

Neutrophils Promote Tumor Progression in Oral Squamous Cell Carcinoma by Regulating EMT and JAK2/STAT3 Signaling Through Chemerin.

Authors - Xiaoyuan Hu
humanWB

J Zhejiang Univ Sci B

Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.

Authors - Xuan Zhou