AGTR1 Monoclonal antibody

AGTR1 Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, rat, pig, mouse

Applications

WB,ELISA

Conjugate

Unconjugated

CloneNo.

2C5G11

Cat No : 66415-1-Ig

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Synonyms

AG2S, AGTR1, AGTR1A, AGTR1B, Angiotensin II type 1 receptor, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, Type 1 angiotensin II receptor



经过测试的应用

Positive WB detected inpig heart tissue, pig skeletal muscle tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

发表文章中的应用

WBSee 1 publications below

产品信息

66415-1-Ig targets AGTR1 in WB, ELISA applications and shows reactivity with human, rat, pig, mouse samples.

Tested Applications WB,ELISA
Cited Applications WB
Tested Reactivity human, rat, pig, mouse
Cited Reactivitymouse
Immunogen AGTR1 fusion protein Ag14461 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name angiotensin II receptor, type 1
Synonyms AG2S, AGTR1, AGTR1A, AGTR1B, Angiotensin II type 1 receptor, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, Type 1 angiotensin II receptor
Calculated Molecular Weight 359 aa, 41 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC022447
Gene Symbol AGTR1
Gene ID (NCBI) 185
RRIDAB_2881787
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP30556
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).

实验方案

Product Specific Protocols
WB protocol for AGTR1 antibody 66415-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseWB

J Adv Res

Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.

Authors - Han Su