Bestrophin-1 Polyclonal antibody
Bestrophin-1 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (1)
Applications
ELISA and More (2)
Conjugate
Unconjugated
验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IF | See 1 publications below |
产品信息
The immunogen of 21910-1-AP is Bestrophin-1 Fusion Protein expressed in E. coli.
| Tested Applications | ELISA |
| Cited Applications | WB, IF |
| Tested Reactivity | human |
| Cited Reactivity | human, rat |
| Immunogen | Bestrophin-1 fusion protein Ag15129 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | bestrophin 1 |
| Synonyms | ARB, BEST, BEST1, bestrophin 1, Bestrophin-1, BMD, TU15B, VMD2 |
| Calculated Molecular Weight | 585 aa, 68 kDa |
| GenBank Accession Number | BC015220 |
| Gene Symbol | BEST1 |
| Gene ID (NCBI) | 7439 |
| RRID | AB_2878944 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O76090 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).
发表文章
| Species | Application | Title |
|---|---|---|
iScience Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration | ||
Sci Rep CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. |
